Functional disruption of MBNL proteins is associated with a number of disease features in the neuromuscular degenerative disorders myotonic dystrophy type 1 and 2 (DM1 and DM2) [26], where MBNL proteins are sequestered in nuclear foci by RNAs bearing expanded CUG or CCUG repeats, respectively [24, 25]. The gene discussed is MBNL1; the disease is myotonic dystrophy type 1.