TWIST1 and breast cancer: Notably, PI3K/AKT signaling induces the phosphorylation of mTORC1, leading to the activation of p70S6K and inactivation of 4EBP1, resulting in increased translation of epithelial–mesenchymal transition (EMT)-related transcription factors, such as Twist, Snail, or Slug, thereby facilitating breast cancer metastasis [15,16].