NEUROD1 and hepatocellular carcinoma: However, while Z-VAD restored the viability of NeuroD1-knocked down HCC-LM3 cells, the effect was slight and it failed to restore the viability of those cells to the level of control (S3H Fig), indicating that while knocking down NeuroD1 could induce apoptosis in HCC cells, it might also have triggered non-apoptotic cell death.