In tumor cells, autophagic cell death is suppressed by the highly expressed phosphoglycerate kinase (PGK1), which suppresses the expression of microtubule-associated protein light chain 3II (LC3-II) and the formation of autophagosomes through binding and phosphorylating proline-rich Akt substrate 40 kDa (PRAS40) [27, 28]. Here, AKT1S1 is linked to neoplasm.