Luciferase reporter assay results showed that knocking down NeuroD1 significantly suppressed the activity of GPX4-Luc-1 in HCC-LM3 and MHCC-97H cells; however, it failed to affect the activities of GPX4-Luc-2, GPX4-Luc-3, and GPX4-Luc-4 (Figs 4D and S6A). Here, NEUROD1 is linked to hepatocellular carcinoma.