Furthermore, alterations in NeuroD1 expression in HCC-LM3 cells negatively regulated the levels of malondialdehyde (MDA; Figs 2F and S4D) and 4-hydroxynonenal (4-HNE; Figs 2G and S4E), the two main products of PUFA peroxidation. The gene discussed is NEUROD1; the disease is hepatocellular carcinoma.