However, treatment with a GPER agonist (G-1) reduced the effects of ovariectomy and was associated with upregulation of UCP2 protein levels in the left ventricle of these rats (OVX+T2D+G-1 vs. OVX+T2D+Veh, P ≤ 0.05). Here, GPER1 is linked to type 2 diabetes mellitus.