International studies on the expression of PTP4A1 based on CTCs are mostly found in lung cancer, but no relevant reports have been reported in esophageal cancer.[6,7] Therefore, this study explored the factors influencing treatment efficacy in patients with esophageal cancer and constructed a prediction model to investigate the value of PTP4A1 expression combined with CTCs in evaluating the occurrence, development, and prognosis of patients with esophageal cancer, thus providing a reliable reference for clinical decision making. The gene discussed is PTP4A1; the disease is lung cancer.