PTP4A1 and neoplasm: Li Chao et al found that microRNAs were related to advanced TNM differentiation, and PTP4A1-mediated phosphorylation was identified as a direct downstream target of microRNAs.[6,19] Tao et al reported that PTP4A1 was related to the status of lymph node metastasis, and the increase in PTP4A1 expression would cause an increase in the tumor recurrence rate, affecting patient outcomes and reducing patient survival.[7]