CA1 and colorectal carcinoma: It has been suggested that low carbonic anhydrase I and carbonic anhydrase II hydratase activities and a corresponding decrease in HCO3− secretion in CRC-infiltrated T lymphocytes may indicate a dysregulation of the local immune response and a consequent loss of effective anticancer mechanisms.[23] In conclusion the factors revealed by GO enrichment analysis corroborate with numerous studies, suggesting that these factors are critical for the development and progression of CRC.