The available data regarding its incidence highlight a 2-fold increase every decade.[1] Familial melanoma constitutes a relatively commonly encountered entity in the global nosological context of melanoma, being situated in direct relationship with cyclin-dependent kinase inhibitor 2A (CDKN2A) and CDK4, 2 genes essentially involved in cellular division, whose potential alterations raise the risk of occurrence of melanocytic malignancies.[2]. The gene discussed is CDK4; the disease is melanoma.