CDKN2A and melanoma: A study by Fątowicz et al found molecular mutations of p14 and p16 proteins in the CDKN2A gene in 95% of melanoma biopsies,[15] a fact that—corroborated with our immunohistochemical discoveries—is congruent with the quasi-perfect relationship with CDKN2A homozygous, heterozygous and monosomic alterations detected via FISH.