CDKN2A mutation is generally correlated with young age at diagnosis, familial aggregation and cases of multiple primary melanoma (MPM).[3] Moreover, it encodes 2 tumor suppressive proteins—p14 and p16—and, up to this date, the documented immunohistochemical expression of these markers has been significantly associated with familial cases of mucous and cutaneous melanoma.[4]. This evidence concerns the gene CDKN2A and cutaneous melanoma.