CDKN2A and pancreatic neoplasm: Major susceptibility gene in melanoma, with over 60 germinal mutations identified at the moment, CDKN2A alterations mainly imply missense mutations in the p16 transcript.[10] The probability of identifying CDKN2A positivity in families with melanoma aggregation increases proportionally with the number of affected members, the presence of relatives with multiple primary melanomas, pancreatic cancer, or young age at the time of the debut of the malignant melanocytic lesion.