MYH9 and senile cataract: Furthermore, the phenotype of a patient with an MYH9 mutation can evolve over time, as supported by previous research.[9] Progressive manifestations that can develop over time include neurological deafness, senile cataracts, and nephritis, which may ultimately progress to end-stage renal disease.[10,11] In the case of our patient and his father, persistent hematuria and proteinuria were observed, necessitating regular monitoring of the kidney function.