Pharmacological studies have shown that Chaihu Jia Longgu Muli decoction has an inhibitory effect on MEK/ERK phosphorylation, reducing oxidative stress damage in individuals and improving the symptoms of insomnia.[33] Clinical trials have demonstrated that Chaihu Jia Longgu Muli decoction significantly improves the sleep quality of insomnia patients. This evidence concerns the gene MAP2K7 and insomnia.