Although the sampling size is not robust enough for definitive conclusions about the effects of aging, PD disease state, or exercise training on ADAR editing in PD, the results provide preliminary evidence that ADAR editing is dysregulated in skeletal muscle in PD, where certain sites have shown lower levels of editing in PD Males compared to Older Males or Younger Males by at least 20%. This evidence concerns the gene ADAR and Parkinson disease.