The intronic variant rs7731626 (5-55444683-G-A), located in the wider IL6ST and ANKRD55 locus (Fig. 3B), is associated with immune-mediated diseases such as Crohn’s disease, rheumatoid arthritis [67], multiple sclerosis [68], systemic lupus erythematosus, and common variable immunodeficiency as suggested by Open Targets Genetics [69] and Database of immune cell eQTLs expression epigenomics (DICE) [34]. This evidence concerns the gene IL6ST and Crohn disease.