This does not rule out borderline DAT-SPECT findings in the premotor phase of Parkinson’s disease, for example in patients referred to DAT-SPECT because of idiopathic rapid eye movement sleep behavior disorder that can precede motor symptoms in α-synucleinopathies including Parkinson’s disease and multiple system atrophy. The gene discussed is SLC6A3; the disease is multiple system atrophy.