In fact, in this model, a reduction in the weight gain of the animals was observed, which was markedly lower than the animals of the C and CD groups and this fact may have influenced the process of bone remodeling in a more shocking way than the process of hyperglycemia, which can mean that the insulin absence is more important for bone healing and development than the deleterious effect of the hyperglycemia .5, 24, 25. The gene discussed is INS; the disease is Hyperglycemia.