Also, genetic alterations in the genome have been reported as somatic mutations in several genes, including NOTCH1, KMT2D, CASP8, AJUBA, NSD1, HLA-A, and TGFBR2, in addition to systemic diseases having an increased risk for developing oral cancers such as Xeroderma Pigmentosum, Fanconi anemia, Congenital Dyskeratosis 26,27,.28 The gene discussed is NOTCH1; the disease is lip and oral cavity carcinoma.