Also, genetic alterations in the genome have been reported as somatic mutations in several genes, including NOTCH1, KMT2D, CASP8, AJUBA, NSD1, HLA-A, and TGFBR2, in addition to systemic diseases having an increased risk for developing oral cancers such as Xeroderma Pigmentosum, Fanconi anemia, Congenital Dyskeratosis 26,27,.28 Here, NOTCH1 is linked to xeroderma pigmentosum.