The results of ChIP-seq and RNA-seq confirmed that BPA promoted the proliferation of uterine leiomyoma cells by acting on X-box binding protein 1 (XBP1) and downstream integrin subunit alpha 2 (ITGA2), thereby activating the PI3K/AKT signaling pathway [138]. The gene discussed is ITGA2; the disease is Uterine leiomyoma.