CCNE2 and endometrial cancer: In another study, BPA (10, 103, and 105 nM) downregulated the expression of miR-149 in the ADP-ribosylation factor 6 (ARF6)-TP53-cyclin E2 (CCNE2) pathway in human endometrial cancer RL95-2 cells, thereby interrupting cell cycle arrest and initiating cancer migration and invasion.