Most often, aluminum hydroxide (an adjuvant) mixed with OVA is used to boost the intraperitoneal sensitization phase, after which an aerosol challenge with OVA results in an OVA-specific IgE response, with Th2 cells producing IL-4, IL-5, IL-10, and IL-13 and the typical pathologic and physiologic features of asthma [33]. Here, IL5 is linked to asthma.