NFE2L1 and cancer: For several SNPs of other antioxidant system genes (TXNRD-1, GPX4, NQO1, NFE2L3, NFE2L1) that prevent the formation of free radicals and reactive oxygen molecules, thereby protecting the cell from oxidative stress, the significant associations with various cancer types and various skin, respiratory system, and digestive tract pathologies [72,73] have been detected.