Focusing on the medical status of the population exposed to pesticide contamination (cardiovascular diseases, gastrointestinal diseases, cancer, autoimmune diseases, diabetes mellitus, hypothyroidism, etc.), we chose SNPs of xenobiotic detoxification genes (CYP1A1, CYP2B6, CYP2D6, CYP2C19, GSTM1, GSTT1, GSTP1, NAT2) [14,21,22] and antioxidant protection (GCLC, GCLM, GPX4, PON1, PON2, PON3, NQO1, SOD1, SOD2, SOD3, AKR1B10, AKR1C1, APOE, NFE2, NFE2L1, NFE2L2, NFE2L3, SRXN1, TXNRD1, UCP3) [9,13,23,24,25,26,27], mutations which are associated with these diseases. This evidence concerns the gene NFE2L1 and cancer.