GPX4 and Renal insufficiency: The glutathione peroxidase enzyme GSH-Px4, due to its unique properties of reducing lipid hydroperoxides, plays an important role in the prevention of pesticide accumulation in the body, protecting against development of cardiovascular diseases [25], renal failure in patients with type 1 diabetes mellitus [58], schizophrenia [59], and chronic obstructive pulmonary disease [60].