Focusing on the medical status of the population exposed to pesticide contamination (cardiovascular diseases, gastrointestinal diseases, cancer, autoimmune diseases, diabetes mellitus, hypothyroidism, etc.), we chose SNPs of xenobiotic detoxification genes (CYP1A1, CYP2B6, CYP2D6, CYP2C19, GSTM1, GSTT1, GSTP1, NAT2) [14,21,22] and antioxidant protection (GCLC, GCLM, GPX4, PON1, PON2, PON3, NQO1, SOD1, SOD2, SOD3, AKR1B10, AKR1C1, APOE, NFE2, NFE2L1, NFE2L2, NFE2L3, SRXN1, TXNRD1, UCP3) [9,13,23,24,25,26,27], mutations which are associated with these diseases. The gene discussed is GPX4; the disease is diabetes mellitus.