Study using qPCR to screen a panel of 90 genes related to the immune response in leprosy in RNA-derived peripheral leukocytes of patients with (n = 94) and without leprosy reactions (n = 57) observed that there is a marked signature for type 1 (reversal reactions) in the blood, comprising genes mostly related to the innate immune responses, including type I IFN components, autophagy/xenophagy, and Parkin and Toll like receptors. The gene discussed is PRKN; the disease is leprosy.