Two possible mechanisms for FcγR-mediated ADE in SARS-CoV-2 infection have been proposed: firstly, mediated by antibody-dependent infection of macrophages via Fc receptors; and secondly, related to the activation and degranulation of mast cells with Fc receptor-bound SARS-CoV-2 antibodies, leading to increased histamine release [20]. This evidence concerns the gene FCGR2A and infection.