The association between sperm PLCZ1 and male infertility in assisted fertilization has been experimentally and clinically established in humans and horses [13,19,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,55,122]. The gene discussed is PLCZ1; the disease is male infertility.