When associated with infertility in men, oocyte activation failure after ICSI has been attributed to PLCZ1 mutations or protein alterations [13,19,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46] in 30 to 40% of failures [31,40,178]. Here, PLCZ1 is linked to Infertility.