CASK and glioblastoma: The same group in 2015 produced recombinant chimeric toxins composed of the PDZ-hCASK (serine kinase calcium/calmodulin-dependent of the MAGUK family binding to CD98) sequence coupled to saporin S6 as monovalent (hCASK-SAP) or bivalent (hCASK(2SAP) toxins and tested their toxicity towards human glioblastoma cell lines (GL15 and U87) [153].