MuSK, a protein present at the neuromuscular junction, is essential in order for AChRs to assemble at the neuromuscular junction; when MuSK is deficient or when antibodies block MuSK’s natural function, AChRs fail to form clusters, resulting in the inefficient transmission of information from the nerve and the development of MG pathophysiology. The gene discussed is MUSK; the disease is myasthenia gravis.