At the same time, he reported that the frequency of HLA-B*8-DRB1*04:04 was high in early-onset MG in Europe at the age of 40 years or younger, and HLA-DRB1*15:01 alleles were high in late-onset MG at the age of 60 years or older. Here, HLA-DRB1 is linked to myasthenia gravis.