Whole exome sequencing analysis, in an ASD patient with complex neurobehavioral phenotypes, who also had epilepsy and another attention disorder, clarified that the Arg-205-to-Gln (R205Q) and Arg-1653-to-Gln (R1635Q) mutations of Plexin-A2, as well as the Leu-487-to-Pro (L487P) mutation of a functionally unidentified protein leucine-rich repeat containing 40 (LRRC40), were critically associated with these symptoms, including ASD. This evidence concerns the gene PLXNA2 and epilepsy.