Homoharringtonine [44], periplocamine [45], dactolisib [46], AZD-8055 [47], anisomycin [38], verrrucarin A [48,49], and BX-795 [50] all have effects on the PI3K/Akt/mTOR pathway in different cancer models, contributing to their antitumor activities. This evidence concerns the gene AKT1 and cancer.