At the same time, the BRICHOS domain has been linked to some human diseases such as familial dementia (Bri2 and Bri3), Alzheimer’s disease (Bri2), respiratory disease (proSP-C), amyloidosis (Bri2, proSP-C), and cancer/tumor suppression (chondromodulin-I, gastrokines 1 and 2) [3]. Here, ITM2B is linked to respiratory system disorder.