Sinulariolide (from the soft coral Sinularia flexibilis) not only inhibited the migratory and invasion capacity (8 μg/mL, 24–48 h) of HA22T hepatocellular carcinoma cells, but additionally reduced the protein levels of p-ERK, p-JNK, p-p38, p-AKT, and p-mTOR [27]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.