This includes 11-dehydrosinulariolide (from the soft coral Sinularia leptoclados), which upregulates stress response pathway markers (PERK, p-PERK, CHOP, and GRP78, amongst others, at 3 μg/mL for 24 h) in oral squamous cell carcinoma cell lines [16]. The gene discussed is EIF2AK3; the disease is squamous cell carcinoma.