Subclass of Verongimorpha: (+)-Aeroplysinin-1 (derived from Verongia aerophoba) reduced the EGF-stimulated proliferative capacity in MCF-7 breast cancer cells (0.5–0.25 μM) as well as EGFR endocytosis and EGFR kinase activity [127]. The gene discussed is EGFR; the disease is breast cancer.