AKT1 and small cell lung carcinoma: 11-dehydrosinulariolide (from cultured Sinularia flexibilis) not only inhibited the proliferative capacity of small cell lung cancer cells (i.e., H1688, 25–50 μM, 24–48 h) but also reduced p-AKT levels along with a corresponding increase in PTEN protein (25 μM, 12–24 h) [25].