Flaccidoxide-13-acetate (from the cultured soft coral Sinularia gibberosa) induced an apoptotic and ER stress response in RT4 and T24 bladder cancer cells, which was associated with the reduced phosphorylation of PI3K and AKT in addition to p-ERK (via Western analyses, 5–20 μM) [32]. This evidence concerns the gene AKT1 and urinary bladder carcinoma.