VIM and Familial prostate cancer: Vimentin: In addition to altering actin dynamics, sinularin (obtained from Sinularia flexibilis, a soft coral) in combination with TGFβ reduced vimentin (an intermediate filament) protein expression (1 μM, 48 h), which may have contributed to the diminished cellular migration/invasion potential of DU145 and PC3 prostate cancer cells [15].