Sinularin (isolated from the cultured soft coral Sinularia flexibilis) not only induced an apoptotic response (20–80 μM, 24 h) in renal 786-O and ACHN cancer cell lines, but this was accompanied by reductions in the expression of p-p85-PI3K, p-AKT, and p-mTOR, while p-JNK, p-ERK, and p-p38 protein levels were elevated (via Western analyses) [30]. This evidence concerns the gene AKT1 and cancer.