Another compound isolated from Sinularia flexibilis, 11-epi-sinulariolide acetate (11-epi-SA, 8 μM), inhibited the migration and invasion of HA22T hepatocellular carcinoma cells coinciding with reduced p-ERK1/2 and p-p38 protein levels along with reduced p-AKT, p-PI3K, and p-mTOR expression [26]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.