AKT1 and hepatocellular carcinoma: 13-Acetoxysarcocrassolide also reduced cellular viability with features of apoptosis (5 μM, 24 h) in HA22T and HepG2 hepatocellular carcinoma cells, associated with reduced p-PI3K, p-AKT, p-mTOR, and p-p70S6K proteins [36].