CGs are classified into three subtypes: type I consists of isolated monoclonal Igs (IgM) and is often associated with plasma cell dyscrasias; type II comprises monoclonal IgM with positive rheumatoid factor (RF) and polyclonal IgG; and type III includes polyclonal IgG and IgM with positive RF [3]. This evidence concerns the gene CD40LG and plasma cell neoplasm.