As mentioned above, miR-223 has been found to be increased in populations with obesity and insulin resistance; furthermore, this miRNA was found to modulate the inflammatory phenotype and macrophage activation through the FBXW7/TLR4 (F-box and WD repeat domain containing 7/toll-like receptor 4) axis. Here, TLR4 is linked to obesity due to melanocortin 4 receptor deficiency.