INS and obesity due to melanocortin 4 receptor deficiency: A cross-sectional study conducted in adolescents with obesity found an association between circulating levels of at least 10 microRNAs and plasma levels of adipokines such as adiponectin, leptin, and other markers of metabolic syndrome such as glucose, insulin, the HOMA-IR index, peptide-C, and plasma levels of lipids such as triglycerides, HDL cholesterol, and LDL cholesterol [32].