SLC27A1 and obesity due to melanocortin 4 receptor deficiency: Another research group used an animal model and in vitro studies to analyse how Let-7b-5p, a miRNA, could regulate genes such as UCP1, FATP1 (fatty acid transport protein-1), ATP5A (ATP synthase α-subunit), PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α) for selfregulation of thermogenesis and oxidative phosphorylation, as well as participate in the hepatic TGF-β (transforming growth factor-beta) signalling pathway and inhibit white adipose tissue beiging, which could also promote the development of non-alcoholic fatty liver disease and obesity [17].