Another study in an animal model showed that mice with obesity and fed a high-fat diet had lower levels of exosomal miR-141-3p than mice with obesity consuming a normal diet, and the decrease in miR-141-3p was associated with reduced Akt (serine/threonine-protein kinase) phosphorylation. This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.