These miRNAs regulate genes such as CHD9 (chromodomain helicase DNA binding protein 9), PTEN (phosphatase and tensin homologue), MTMR12 (myotubularin related protein 12), TBL1X (transducin beta-like 1 X-linked), and CPOX (coproporphyrinogen oxidase), which are involved in lipid metabolism, inflammatory status and insulin resistance, suggesting these miRNAs as biomarkers of obesity in adolescents [29]. The gene discussed is CPOX; the disease is obesity due to melanocortin 4 receptor deficiency.