In contrast, steroid derivatives that were only found in T. cylindrica, e.g., estra-1,3,5(10)-trien-17-β-ol-17-α-butadinyl-3-methoxy; 17-(1,5-dimethylhexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol, and stigmasta-5,24(28)-dien-3-ol, (3β,24Z)-, showed the ability to bind to both anti-DM and anti-COVID-19 target proteins, i.e., α-glucosidase, α-amylase, ACE2, and TMPRSS2. Here, ACE2 is linked to diabetes mellitus.