Further, in silico molecular docking assessments have shown that three compounds detected in the T. cylindrica lipophilic extract, identified as steroid derivatives, have the ability to inhibit DM and COVID-19 protein targets, α-amylase, α-glucosidase, ACE2, and TMRPSS2, and their binding affinity was higher than their respective positive controls. This evidence concerns the gene ACE2 and COVID-19.