As an example of this modeling, we performed a serial dilution assay of the oncohistone H3K36M and the mutant H3K36R, which has been identified in T-cell acute lymphoblastic leukemia, though its oncogenicity is uncertain [101], and is expressed both in the presence of wildtype H3 (hht2-K36M/R HHT1 cells) and as the sole copy of H3 (hht2-K36M/R hht1Δ) (Figure 4B). The gene discussed is ACVRL1; the disease is T-cell acute lymphoblastic leukemia.