Linear regression between cell densities of PD-1+ or PD-L1+ versus patient age (Figure 6A,B) showed correlations between variables (R2 = 0.0235 for PD-1; and R2 = 0.0033 for PD-L1), suggesting that fungal infection results in an altered expression pattern of these cell exhaustion markers; therefore, the existing correlation in human physiology is lost. The gene discussed is CD274; the disease is fungal infectious disease.