TNF and bacterial infectious disease with sepsis: In parallel, the histological score of colons (neither liver nor kidney), cytokines from the liver tissue (TNF-α and IL-6, but not IL-10), and cytokines from kidney samples (TNF-α, IL-6, and IL-10), inflammatory cell infiltration of the internal organs (livers, kidneys, and colons), and fungemia (but not bacteremia) in macrophage-depleted CLP mice were also higher than those in Liposome-CLP mice (Figure 3A–L, Figure 4A–F and Figure 5A–C).