As such, there was an enhanced severity of sepsis in macrophage-depleted mice with CLP compared with CLP in the Lipo group, as indicated by the survival analysis, leaky gut, serum cytokines (TNF-α and IL-10, but not IL-6), serum creatinine, and alanine transaminase (Figure 2A–H). The gene discussed is TNF; the disease is Sepsis.