We compared the phylogenetic tree established using polygenic data with the cluster analysis tree established via NRPS (A-P-C), NR-PKS (SAT-KS-AT-PT-ACP-ACP-Te), HR-PKS (KS-AT-DH-ER-KR-ACP), and hybrid PKS-NRPS (KS-AT-DH-MT-KR-P-C-A-P-Te), respectively. The gene discussed is NDUFAB1; the disease is tetrasomy 12p.