In an analysis of the Atherosclerosis Risk in Communities (ARIC) cohort, the addition of NT-proBNP significantly improved the Framingham Heart Study (FHS), Health Aging and Body Composition (ABC), and ARIC HF risk prediction models, with the categorical Net Reclassification Index (NRI) being 0.18, 0.12, and 0.13, respectively [8]. The gene discussed is NPPB; the disease is hydrops fetalis.