NPPB and hydrops fetalis: In a prospective study of 3346 patients without HF, a mean follow-up of 5.2 years, BNP > 20 pg/mL in men, and BNP > 23.3 pg/mL in women was found to be associated with a significantly higher risk of new-onset HF (HR 3.07, p = 0.002) [7].