In the Framingham Offspring Cohort, increasing levels of galectin-3 were associated with an increased risk of incident HF (HR 1.28 per 1 SD increase in log galectin-3; 95% CI 1.14–1.43; p < 0.0001), which remained significant after adjustment for clinical variables and BNP (HR 1.23; 95% CI 1.04–1.47; p = 0.02) [26]. This evidence concerns the gene NPPB and hydrops fetalis.