Using a biomarker score composed of hs-cTnT ≥6 ng/L, NT-pro-BNP ≥125 pg/mL, high-sensitivity CRP ≥3 mg/L, and LVH by electrocardiography (with 1 point for each abnormal parameter), the authors reported that the 5-year risk of HF increased in a graded fashion with an increasing biomarker score, with the highest risk being among those with scores of ≥3 (5-year risk of HF in patients with diabetes: 12.0%; patients with pre-diabetes: 7.8%). The gene discussed is CRP; the disease is diabetes mellitus.