Similarly, in the Heart and Soul study, in participants with stable coronary artery disease, participants with 5-year changes in the highest quartile (≥223 pg/mL increase in NT-proBNP) had an almost 4-fold greater risk of subsequent HF or CV death than those in the lowest quartile of ≤−5 pg/mL (HR 3.8; 95% CI 2.0–7.3; p < 0.001) [11]. This evidence concerns the gene NPPB and hydrops fetalis.