In a study including 9698 ARIC study participants aged 54–74 years who were free from coronary heart disease (CHD), stroke, and HF, Saunders et al. found that compared with participants with undetectable levels, those with high-sensitive cardiac troponin T (hs-cTnT) levels in the highest category (≥0.014 μg/L) had a significantly increased risk of HF (HR = 5.95; 95% CI 4.47–7.92) after adjusting for traditional cardiac risk factors, kidney function, high-sensitivity C-reactive protein (CRP), and NT-proBNP [15]. This evidence concerns the gene NPPB and coronary artery disorder.