Using the ARIC cohort, Jia et al. used NT-proBNP levels, measured 6 years apart and reported that the percent change in NT-proBNP, per 1-SD increase, was positively associated with an increased risk of HF (HR 1.06, 95% CI 1.02–1.10) and death (HR 1.05, 95% CI 1.03–1.08). This evidence concerns the gene NPPB and hydrops fetalis.