In a post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), intensive systolic blood pressure (SBP) control led to greater absolute risk reduction (ARR) in death and HF in the sub-group with elevated hscTnT (≥14 ng/L) and NTproBNP (≥125 pg/mL) compared to those with neither biomarker elevation: 7.8% (95% CI 3.3–11.3%) vs. 1.7% (95% CI 0.8–2.3%), respectively [13]. Here, NPPB is linked to hydrops fetalis.