Additionally, in an analysis from the Cardiovascular Health Study (CHS), a significant increase in NT-proBNP (>25% increase) at follow-up (2–3 years) was associated with an increased risk of HF (HR 2.06; 95% CI 1.56–2.72) and CVD (HR 1.88; 95% CI: 1.37–2.57), while those with a significant decrease in NT-proBNP (>25% decrease to < or = 190 pg/mL) had a lower risk of HF (HR 0.58; 95% CI: 0.36–0.93) and CVD (HR 0.57; 95% CI 0.32–1.01) compared with individuals with unchanged values [12]. Here, NPPB is linked to hydrops fetalis.