In the St Vincent’s Screening to Prevent Heart Failure (STOP-HF) study, Watson et al. found that a combination of biomarkers, high-sensitivity troponin I (hsTnI), BNP, and galectin-3 significantly predicted future HFpEF using both baseline (AUC 0.82 (0.73, 0.92)) and follow-up data (AUC 0.86 (0.79, 0.94)). Here, NPPB is linked to hydrops fetalis.