In the Biomarkers for Cardiovascular Risk Assessment in Europe consortium study, the addition of hs-cTnI and NT-proBNP to a prognostic model consisting of CVRFs improved HF prediction, with the best predictive value for incident HF (C-index = 0.862) being achieved by combining CVRFs with both hs-cTnI and NT-proBNP [36]. Here, TNNI3 is linked to hydrops fetalis.