Moreover, in the Mild Cognitive Impairment group, the levels of both HbA1c NGSP and IFCC (R −0.224; p < 0.05) and cystatin C (R 0.296; p < 0.05) exhibited a significant negative correlation against the MoCA-Ina score, whereas the SIRT1 levels showed a significant positive correlation against the MoCA-Ina score in participants with Normal Cognitive (R 0.437; p <0.05). This evidence concerns the gene SIRT1 and Cognitive impairment.