NES and melanoma: SOX10 and Nestin in Melanoma Development:Nestin, an intermediate filament found in neural progenitor cells, melanomas, and melanocytic nevi, shows statistically significant co-expression with SOX10 in primary melanomas;SOX10 plays a key role in Nestin activation in primary melanoma cells, suggesting that SOX10 is a major mediator of early melanoma development.