In an attempt to demonstrate the clinical and morphological heterogeneity between gastrointestinal mesenchymal tumors with neurotrophic tyrosine receptor kinase (NTRK) gene rearrangements and gastrointestinal stromal tumors, Atiq et al. reported consistently absent SOX10 expression in eight mesenchymal tumors in the gastrointestinal tract with NTRK1 or NTRK3 rearrangements [54]. This evidence concerns the gene SOX10 and gastrointestinal stromal tumor.