A decrease in TNF-α was associated with the enrichment of Bacteroidetes, the most abundant edge in the lung of the healthy subject; In a similar case, in a study by Alison J. Dicker 2021, in a group of patients with bronchiectasis (both stable and with exacerbations), a microbiome dominated by Proteobacteria and Firmicutes was found [30]. The gene discussed is TNF; the disease is bronchiectasis.