Among them, adipokines, in addition to classic cytokines, such as tumor necrosis factor α (TNF-α), interleukin (IL-1β, IL-8, and IL-6), C-reactive protein (CRP), interferon-γ (IFN-γ), or chemoattractant protein-1 (MCP-1), are mostly secreted in adipose tissues from adipocytes, and adipokines are found to be released from periodontal tissues to regulate the inflammation process in the comorbidity of periodontitis and obesity [14,15]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.