According to the currently available evidence from clinical studies, laboratory animal science, and in vitro studies, visfatin and RBP4 may exert proinflammatory effects and there is a significant positive correlation between the level of visfatin/RBP4 and the degree of alveolar bone resorption in patients with obesity and periodontitis. Here, RBP4 is linked to obesity due to melanocortin 4 receptor deficiency.