TP53 and cancer: Supplementary Figure S5A shows that pan-cancer TP53 expression was negatively correlated with the immune cells. At the same time, we also investigated the correlation between TP53 expression and immune infiltration in HNSC (R = 0.24), LIHC (R = 0.26), THYM (R = 0.17), STAD (R = 0.16), LGG (R = 0.01), and KIRC (R = 0.16). The results showed that TP53 expression was positively correlated with immune cell infiltration (Figure 8E–J). Information on TP53 expression and tumor-related immune infiltration is shown in Supplementary Table S5.