Moreover, the higher mRNA levels of the four transcription factors (TCF7, TCF7L1, TCF7L2, LEF1) propagating the signals in the Wnt/β-catenin pathway (Figure 3B) also corroborate the pro-tumorigenic status of Wnt signaling in HNSCC. Here, TCF7L2 is linked to head and neck squamous cell carcinoma.