Figure 2 presents data generated based on the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium database. The expression of PKM and LDHA in HNSCC protein samples was indeed increased. In turn, the protein level of PFKM was significantly lower compared to normal samples, although its transcript level was upregulated (Figure 1A). The gene discussed is PFKM; the disease is head and neck squamous cell carcinoma.