Based on TCGA database analysis, we showed that PORCN, CTNNB1, and CREBBP genes are overexpressed in HNSCC, similarly to AKT1 and four transcription factors acting downstream of the Wnt/β-catenin signaling pathway, which further corroborates the aberrant activation of Wnt signaling. This evidence concerns the gene CTNNB1 and head and neck squamous cell carcinoma.