In a recent study, ADRA2A overexpression was observed to suppress proliferation and to promote apoptosis through the repression of PI3K/AKT/mTOR signaling in cervical cancer [26], another signaling axis associated with platinum resistance in several contexts [6]; however, to date, no work has demonstrated the impact of ADRA2A activity in OvCa development or treatment specifically. This evidence concerns the gene AKT1 and cervical cancer.