To increase the clinical relevancy of our findings, an evaluation of whether ADRA2A activity is relevant in a more physiologic model system that includes components of the OvCa tumor microenvironment (TME) (as performed in a recent study [18]) is required to improve the translatability of these findings, considering that cancer-associated fibroblasts in the TME are thought to significantly contribute to platinum resistance in multiple contexts [29,30]. This evidence concerns the gene ADRA2A and neoplasm.