ADRA2A and breast carcinoma: Additionally, beta-adrenergic activation has been associated with remodeling of the extracellular matrix to promote invasive phenotypes in breast cancer [34], which may be, in part, due to the potential cAMP-mediated epithelial–mesenchymal transition (EMT) [35,36]; however, whether ADRA2A inhibition of this signaling pathway results in suppression of the EMT is still to be determined.