Second, the reports of lncRNAs with both oncogenic and tumor-suppressor roles depending on the context [114,115,116] imply that RRN3P3 can act as an oncogene in breast cancer and as a tumor suppressor in CCR; this would require experimental validation to better understand the role of this lncRNA in determining tumor phenotype. Here, RRN3P3 is linked to breast carcinoma.