Furthermore, metformin treatment leads to increased synthesis of neurotrophic factors, like nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF), while it also induces the expression of mature oligodendrocyte markers and the activation of AMPK in the CPZ-induced demyelination mouse model [72]. The gene discussed is BDNF; the disease is Peripheral demyelination.