In the cited study, the authors compared the expressions of all aquaporin encoding genes (AQP1/2/3/4/5/6/7/8/9/10/11) in 533 tumor cases with 72 normal cases, using the uniform fold-change threshold of 1.50× and p-value < 0.01, to decide whether a gene was significantly regulated. The gene discussed is AQP1; the disease is neoplasm.