SOX2-OT, SOX6, SOX8, SOX21 and SRY genes were connected with tobacco smoking; SOX2-OT, SOX6, SOX21 and SOX30- were connected with lymph node neck dissection and lymphovascular invasion; and SOX2-OT, SOX8 and SOX30 were connected with HPV in p16 test two with regard to gender (SOX21, SRY), cancer stage (SOX6, SOX21) and grade (SOX8, SOX30) and one gene with age (SRY), alcohol (SRY), T stage (SOX8) and N stage (SOX30). The gene discussed is SOX8; the disease is cancer.