The identified nsSNPs, Y591D/N, W435C, and F104S are recognized MPL mutations linked to various hematological conditions such as Essential Thrombocythemia (ET) and Congenital Amegakaryocytic Thrombocytopenia (CAMT) [31,33]. Here, MPL is linked to congenital amegakaryocytic thrombocytopenia 1.