Together with SULTR1.2, the protein has been characterized as a high-affinity sulfate transporter, localized in the cortex, epidermis and root hairs and usually detectable upon S deficiency [42] and reportedly under the excess of some metall(oid)s, such as Zn, Cd, Cr and Se [43,44,45,46]. This evidence concerns the gene SLC26A2 and hyperinsulinemic hypoglycemia, familial, 4.