Various immune cells are involved in anti-cancer immunity, including [33] cytotoxic T cells (CD8+ T), which can directly recognize and destroy cancer cells by releasing cytotoxic molecules; B cells, which produce antibodies that can mark cancer cells for destruction, especially in antibody-dependent cellular cytotoxicity (ADCC); natural killer (NK) cells, which can directly kill cancer cells and help modulate the immune response; and dendritic cells, which help activate T cells by presenting cancer cell antigens to them. This evidence concerns the gene CD8A and cancer.