First, they demonstrated that Nano-reshaper remodeled the local glioblastoma microenvironment, rectifying abnormal blood vessel structure and decreasing levels of glioblastoma-derived immunosuppressive cytokines such as TGF-β and IL-10, resulting in lower levels of Tregs and M2 phenotype TAMs [66]. This evidence concerns the gene TGFB1 and glioblastoma.