CD274 and glioblastoma: Given that ferroptosis has been implicated in glioblastoma immunosuppression and tumor progression, Liu and colleagues found that combined treatment with a ferroptosis inhibitor and PD-1/PD-L1 blockade reversed the immunosuppressive phenotype in tumor-bearing mice, resulting in prolonged survival time and reduced tumor size compared to treatment with PD-1/PD-L1 blockade alone [52] (Table 1).