NFKB1 and viral infectious disease: For example, ozone used in many oxygen–ozone therapy approaches, such as major autohemotherapy (O2-O3-MAHT), targets inflammatory mechanisms by acting on more complex intracellular signaling pathways, modulating the interplay between Nrf2/NF-κB and the mitochondria-associated inflammasome NLRP3, occurring for viral diseases and other inflammatory pathologies [83,84].